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Structure of anti-angiotensin II TYPE2 receptor antibody (D5711-4A03)

Analyse Structure of anti-angiotensin II TYPE2 receptor antibody (D5711-4A03) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XLI
Type: protein
Length: 866 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fabl; Fabh
Pockets: 10 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
a, b	Fabl	protein	213	5% helix, 52% strand	—
c, d	Fabh	protein	220	4% helix, 51% strand	—

Pockets

10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	593	0.66	0.76	57	empty
2	62	0.64	0.93	18	empty
3	52	0.63	0.94	17	empty
4	413	0.59	0.75	46	empty
5	335	0.58	0.76	33	empty

Interfaces

4 interfaces between chains.

b–d · 1801 Å² buried · 11 hydrogen bonds · protein-protein
a–c · 1753 Å² buried · 16 hydrogen bonds · protein-protein
b–c · 187 Å² buried · 6 hydrogen bonds · protein-protein
a–b · 111 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

5XLI · Structure of anti-Angiotensin II type2 receptor antibody (D5711-4A03) · the same entry in another collection · chain a against a, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5XLI · PDBe 5XLI

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