Research workbench
Crystal structure of plant receptor ERL1-tmm in complexe with EPF2
Analyse Crystal structure of plant receptor ERL1-tmm in complexe with EPF2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5XKJ
- Type
- protein
- Length
- 1,842 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein too many mouths; Protein epidermal patterning factor 2; Lrr receptor-like…
- EC
- 2.7.11.1
- UniProt
- Q9SSD1, Q8LC53, C0LGW6
- Pockets
- 16 · best druggability 0.84
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, D | Protein too many mouths | protein | 363 | 19% helix, 19% strand | Q9SSD1 |
| E, F | Protein epidermal patterning factor 2 | protein | 45 | 0% helix, 31% strand | Q8LC53 |
| A, B | Lrr receptor-like SERINE/THREONINE-protein kinase ERL1 (EC 2.7.11.1) | protein | 513 | 19% helix, 17% strand | C0LGW6 |
Pockets
16 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 816 | 0.84 | 0.87 | 103 | empty |
| 2 | 796 | 0.84 | 0.87 | 100 | empty |
| 3 | 299 | 0.60 | 0.78 | 28 | empty |
| 4 | 229 | 0.55 | 0.78 | 29 | empty |
| 5 | 89 | 0.50 | 0.83 | 19 | empty |
Interfaces
8 interfaces between chains.
- C–A · 1690 Ų buried · 21 hydrogen bonds · protein-protein
- D–B · 1646 Ų buried · 22 hydrogen bonds · protein-protein
- E–A · 886 Ų buried · 10 hydrogen bonds · protein-protein
- B–F · 877 Ų buried · 10 hydrogen bonds · protein-protein
- C–E · 752 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 5XKJ · Crystal structure of plant receptor ERL1-TMM in complexe with EPF2 · the same entry in another collection · chain F against F, TM-score 1.00
- Q9SSD1 · AlphaFold monomer V2.0 prediction for protein too many mouths (Q9SSD1) · a predicted model of the same protein · chain C against A, TM-score 0.99
- C0LGW6 · AlphaFold monomer V2.0 prediction for lrr receptor-like SERINE/THREONINE-protein kinase… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q8LC53 · AlphaFold monomer V2.0 prediction for protein epidermal patterning factor 2 (Q8LC53) · a predicted model of the same protein · chain F against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9SSD1
- Every structure of UniProt Q8LC53
- Every structure of UniProt C0LGW6
- Elsewhere: RCSB PDB 5XKJ · PDBe 5XKJ · UniProt Q9SSD1 · UniProt Q8LC53 · UniProt C0LGW6
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