Research workbench
Plant receptor ERL1-tmm in complex with peptide EPF1
Analyse Plant receptor ERL1-tmm in complex with peptide EPF1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5XJO
- Type
- protein
- Length
- 1,864 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lrr receptor-like SERINE/THREONINE-protein kinase ERL1; Protein epidermal patterning…
- EC
- 2.7.11.1
- UniProt
- C0LGW6, Q8S8I4, Q9SSD1
- Pockets
- 12 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Lrr receptor-like SERINE/THREONINE-protein kinase ERL1 (EC 2.7.11.1) | protein | 523 | 20% helix, 22% strand | C0LGW6 |
| F, E | Protein epidermal patterning factor 1 | protein | 42 | 0% helix, 40% strand | Q8S8I4 |
| C, D | Protein too many mouths | protein | 367 | 18% helix, 22% strand | Q9SSD1 |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1070 | 0.82 | 0.83 | 101 | empty |
| 2 | 1179 | 0.81 | 0.82 | 121 | empty |
| 3 | 126 | 0.52 | 0.81 | 23 | empty |
| 4 | 173 | 0.50 | 0.78 | 30 | empty |
| 5 | 84 | 0.48 | 0.82 | 19 | empty |
Interfaces
6 interfaces between chains.
- D–B · 1632 Ų buried · 27 hydrogen bonds · protein-protein
- A–C · 1625 Ų buried · 27 hydrogen bonds · protein-protein
- A–E · 687 Ų buried · 10 hydrogen bonds · protein-protein
- F–B · 667 Ų buried · 10 hydrogen bonds · protein-protein
- E–C · 449 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 5XJO · Plant receptor ERL1-TMM in complex with peptide EPF1 · the same entry in another collection · chain B against B, TM-score 1.00
- Q9SSD1 · AlphaFold monomer V2.0 prediction for protein too many mouths (Q9SSD1) · a predicted model of the same protein · chain C against A, TM-score 1.00
- C0LGW6 · AlphaFold monomer V2.0 prediction for lrr receptor-like SERINE/THREONINE-protein kinase… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q8S8I4 · AlphaFold monomer V2.0 prediction for protein epidermal patterning factor 1 (Q8S8I4) · a predicted model of the same protein · chain E against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C0LGW6
- Every structure of UniProt Q8S8I4
- Every structure of UniProt Q9SSD1
- Elsewhere: RCSB PDB 5XJO · PDBe 5XJO · UniProt C0LGW6 · UniProt Q8S8I4 · UniProt Q9SSD1
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