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CARK1 phosphorylates aba receptors

Analyse CARK1 phosphorylates aba receptors in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XD6
Type: protein
Length: 564 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein kinase superfamily protein
UniProt: Q9LUT0
Ligands: ANP, MG
Pockets: 5 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein kinase superfamily protein	protein	282	44% helix, 16% strand	Q9LUT0
B	Protein kinase superfamily protein	protein	282	43% helix, 16% strand	Q9LUT0

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	299	0.70	0.84	29	ANP, MG
2	714	0.70	0.77	46	empty
3	264	0.61	0.80	27	ANP, MG
4	50	0.31	0.76	13	empty
5	61	0.31	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 498 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

5XD6 · CARK1 phosphorylates ABA receptors · the same entry in another collection · chain A against A, TM-score 1.00
Q9LUT0 · AlphaFold monomer V2.0 prediction for receptor-like cytoplasmic kinase 1 (Q9LUT0) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9LUT0
Elsewhere: RCSB PDB 5XD6 · PDBe 5XD6 · UniProt Q9LUT0

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