Research workbench
Dengue virus 4 NS3 helicase D290A mutant
Analyse Dengue virus 4 NS3 helicase D290A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5XC7
- Type
- protein
- Length
- 451 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NS3 helicase
- UniProt
- M9P7S0
- Ligands
- CL
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NS3 helicase | protein | 451 | 32% helix, 18% strand | M9P7S0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1108 | 0.83 | 0.84 | 95 | GOL, CL |
| 2 | 482 | 0.73 | 0.82 | 56 | empty |
| 3 | 95 | 0.47 | 0.81 | 19 | empty |
| 4 | 89 | 0.42 | 0.79 | 19 | empty |
| 5 | 53 | 0.25 | 0.73 | 18 | empty |
Compared structures
- 5XC7 · Dengue Virus 4 NS3 Helicase D290A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt M9P7S0
- Elsewhere: RCSB PDB 5XC7 · PDBe 5XC7 · UniProt M9P7S0
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