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Crystal structure of full length native tylp, a tetr regulator from streptomyces fradiae
Analyse Crystal structure of full length native tylp, a tetr regulator from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5XAZ
- Type
- protein
- Length
- 1,738 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-butyrolactone receptor protein
- UniProt
- Q9XCC7
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 6 distinct chains · 71% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Gamma-butyrolactone receptor protein | protein | 223 | 72% helix, 2% strand | Q9XCC7 |
| H | Gamma-butyrolactone receptor protein | protein | 211 | 71% helix, 1% strand | Q9XCC7 |
| C, G | Gamma-butyrolactone receptor protein | protein | 213 | 71% helix, 1% strand | Q9XCC7 |
| D | Gamma-butyrolactone receptor protein | protein | 220 | 74% helix, 2% strand | Q9XCC7 |
| E | Gamma-butyrolactone receptor protein | protein | 213 | 69% helix, 1% strand | Q9XCC7 |
| F | Gamma-butyrolactone receptor protein | protein | 222 | 71% helix, 2% strand | Q9XCC7 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1027 | 0.81 | 0.82 | 85 | empty |
| 2 | 991 | 0.79 | 0.81 | 81 | empty |
| 3 | 472 | 0.75 | 0.84 | 58 | empty |
| 4 | 435 | 0.74 | 0.84 | 59 | empty |
| 5 | 459 | 0.73 | 0.83 | 65 | empty |
Interfaces
11 interfaces between chains.
- F–G · 1561 Ų buried · 6 hydrogen bonds · protein-protein
- D–E · 1506 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 1496 Ų buried · 6 hydrogen bonds · protein-protein
- A–H · 1494 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 400 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5XAZ · Crystal structure of full length native tylp, a tetr regulator from streptomyces fradiae · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9XCC7
- Elsewhere: RCSB PDB 5XAZ · PDBe 5XAZ · UniProt Q9XCC7
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