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Crystal structure of animalia-specific tRNA deacylase from mus musculus

Analyse Crystal structure of animalia-specific tRNA deacylase from mus musculus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XAQ
Type: protein
Length: 327 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable D-tyrosyl-TRNA(TYR) deacylase 2
EC: 3.1.-.-
UniProt: Q8BHA3
Pockets: 2 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable D-tyrosyl-TRNA(TYR) deacylase 2 (EC 3.1.-.-)	protein	166	25% helix, 36% strand	Q8BHA3
B	Probable D-tyrosyl-TRNA(TYR) deacylase 2 (EC 3.1.-.-)	protein	161	26% helix, 37% strand	Q8BHA3

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	251	0.59	0.79	35	empty
2	200	0.58	0.80	32	empty

Interfaces

1 interface between chains.

A–B · 1608 Å² buried · 41 hydrogen bonds · protein-protein

Compared structures

5XAQ · Crystal structure of Animalia-specific tRNA deacylase from Mus musculus · the same entry in another collection · chain A against A, TM-score 1.00
Q8BHA3 · AlphaFold monomer V2.0 prediction for D-aminoacyl-tRNA deacylase 2 (Q8BHA3) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8BHA3
Elsewhere: RCSB PDB 5XAQ · PDBe 5XAQ · UniProt Q8BHA3

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