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Crystal structure of inositol 1,4,5-trisphosphate receptor cytosolic domain with inositol 1,4,5-trisphosphate

Analyse Crystal structure of inositol 1,4,5-trisphosphate receptor cytosolic domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5XA1
Type: protein
Length: 2,514 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inositol 1,4,5-trisphosphate receptor type 1
UniProt: P11881
Ligands: I3P
Pockets: 20 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Inositol 1,4,5-trisphosphate receptor type 1	protein	1257	42% helix, 11% strand	P11881

Ligands and binding sites

I3P · D-myo-inositol-1,4,5-triphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1006	0.79	0.81	118	empty
2	1173	0.77	0.79	113	empty
3	832	0.74	0.78	83	empty
4	643	0.73	0.80	78	empty
5	635	0.73	0.80	71	empty

Compared structures

5XA1 · Crystal structure of inositol 1,4,5-trisphosphate receptor cytosolic domain with inositol… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11881
Elsewhere: RCSB PDB 5XA1 · PDBe 5XA1 · UniProt P11881

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