Research workbench
Crystal structure of the ketone reductase CHKRED20 from the genome of chryseobacterium sp. CA49
Analyse Crystal structure of the ketone reductase CHKRED20 from the genome of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5X8H
- Type
- protein
- Length
- 992 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Short-chain dehydrogenase reductase
- UniProt
- X2D0L0
- Pockets
- 11 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Short-chain dehydrogenase reductase | protein | 248 | 50% helix, 16% strand | X2D0L0 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 883 | 0.86 | 0.88 | 69 | empty |
| 2 | 534 | 0.70 | 0.79 | 44 | empty |
| 3 | 530 | 0.69 | 0.78 | 49 | empty |
| 4 | 686 | 0.68 | 0.76 | 61 | empty |
| 5 | 363 | 0.59 | 0.76 | 41 | empty |
Interfaces
6 interfaces between chains.
- B–C · 1622 Ų buried · 27 hydrogen bonds · protein-protein
- A–D · 1604 Ų buried · 28 hydrogen bonds · protein-protein
- A–B · 1393 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 1389 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 263 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5X8H · Crystal structure of the ketone reductase ChKRED20 from the genome of Chryseobacterium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt X2D0L0
- Elsewhere: RCSB PDB 5X8H · PDBe 5X8H · UniProt X2D0L0
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