Research workbench
Crystal structure of casein kinase I homolog 1
Analyse Crystal structure of casein kinase I homolog 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5X18
- Type
- protein
- Length
- 588 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Casein kinase I homolog 1
- EC
- 2.7.11.1
- UniProt
- P23291
- Pockets
- 5 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Casein kinase I homolog 1 (EC 2.7.11.1) | protein | 294 | 37% helix, 18% strand | P23291 |
Ligands and binding sites
- GOL · Glycerol · additive · 5 copies · chains A, B
- MLA · Malonic acid · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 228 | 0.57 | 0.78 | 34 | GOL |
| 2 | 198 | 0.55 | 0.79 | 26 | GOL |
| 3 | 306 | 0.52 | 0.74 | 40 | empty |
| 4 | 53 | 0.37 | 0.80 | 14 | empty |
| 5 | 57 | 0.28 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 139 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23291
- Elsewhere: RCSB PDB 5X18 · PDBe 5X18 · UniProt P23291
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.