Research workbench
Crystal structure of zika virus NS5 RNA-dependent RNA POLYMERASE(RDRP)
Analyse Crystal structure of zika virus NS5 RNA-dependent RNA POLYMERASE(RDRP) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WZ3
- Type
- protein
- Length
- 565 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NS5 rdrp
- UniProt
- A0A1B2ZC85
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NS5 rdrp | protein | 565 | 50% helix, 10% strand | A0A1B2ZC85 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 643 | 0.65 | 0.75 | 62 | empty |
| 2 | 64 | 0.43 | 0.81 | 18 | empty |
| 3 | 100 | 0.40 | 0.76 | 16 | empty |
| 4 | 62 | 0.27 | 0.73 | 17 | empty |
Compared structures
- 5WZ3 · Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase(RdRP) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1B2ZC85
- Elsewhere: RCSB PDB 5WZ3 · PDBe 5WZ3 · UniProt A0A1B2ZC85
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