Research workbench
Structure of a pancreatic ATP-sensitive potassium channel
Analyse Structure of a pancreatic ATP-sensitive potassium channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WUA
- Type
- protein
- Length
- 6,540 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-sensitive inward rectifier potassium channel 11, superfolder GFP; SUR1
- UniProt
- Q61743
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 56% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | ATP-sensitive inward rectifier potassium channel 11, superfolder GFP | protein | 323 | 28% helix, 19% strand | Q61743 |
| E, F, G, H | SUR1 | protein | 1312 | 63% helix, 6% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 905 | 0.84 | 0.86 | 110 | empty |
| 2 | 387 | 0.83 | 0.91 | 39 | empty |
| 3 | 880 | 0.82 | 0.84 | 125 | empty |
| 4 | 713 | 0.80 | 0.84 | 93 | empty |
| 5 | 835 | 0.80 | 0.83 | 111 | empty |
Interfaces
14 interfaces between chains.
- A–B · 3301 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 3243 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 3225 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 3135 Ų buried · 10 hydrogen bonds · protein-protein
- B–F · 575 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5WUA · Structure of a Pancreatic ATP-sensitive Potassium Channel · the same entry in another collection · chain H against H, TM-score 1.00
- Q61743 · AlphaFold monomer V2.0 prediction for ATP-sensitive inward rectifier potassium channel 11… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61743
- Elsewhere: RCSB PDB 5WUA · PDBe 5WUA · UniProt Q61743
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