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Crystal structure of rnp complex

Analyse Crystal structure of rnp complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5WTK
Type: protein + RNA
Length: 1,255 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CRISPR-associated endoribonuclease C2C2; RNA (58-mer)
EC: 3.1.-.-
UniProt: P0DOC6
Pockets: 20 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CRISPR-associated endoribonuclease C2C2 (EC 3.1.-.-)	protein	1215	57% helix, 4% strand	P0DOC6
B	RNA (58-mer)	rna	40	—	—

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	615	0.83	0.88	74	empty
2	630	0.82	0.87	69	empty
3	444	0.82	0.90	49	empty
4	651	0.76	0.82	71	empty
5	626	0.75	0.82	42	empty

Interfaces

1 interface between chains.

A–B · 4543 Å² buried · 93 hydrogen bonds · protein-nucleic

Compared structures

5WTK · Crystal structure of RNP complex · the same entry in another collection · chain A against A, TM-score 1.00
P0DOC6 · AlphaFold monomer V2.0 prediction for CRISPR-associated endoribonuclease CAS13A (P0DOC6) · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DOC6
Elsewhere: RCSB PDB 5WTK · PDBe 5WTK · UniProt P0DOC6

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