Research workbench
Crystal structure of the Fab fragment of anti-hav antibody R10
Analyse Crystal structure of the Fab fragment of anti-hav antibody R10 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WTG
- Type
- protein
- Length
- 858 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab light chain; Fab heavy chain
- Pockets
- 9 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Fab light chain | protein | 212 | 6% helix, 52% strand | — |
| B, D | Fab heavy chain | protein | 217 | 4% helix, 55% strand | — |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 908 | 0.79 | 0.81 | 104 | empty |
| 2 | 1015 | 0.76 | 0.79 | 93 | empty |
| 3 | 287 | 0.58 | 0.78 | 33 | empty |
| 4 | 133 | 0.48 | 0.78 | 23 | empty |
| 5 | 129 | 0.45 | 0.77 | 23 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1999 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1917 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 579 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 479 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 175 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 5WTG · Crystal structure of the Fab fragment of anti-HAV antibody R10 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5WTG · PDBe 5WTG
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