Research workbench
Escherichia COLI uracil-DNA glycosylase complex with uracil- DNA glycosylase inhibitor protein
Analyse Escherichia COLI uracil-DNA glycosylase complex with uracil- DNA glycosylase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1LQM
- Type
- protein
- Length
- 1,227 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uracil-DNA glycosylase; Uracil-DNA glycosylase inhibitor
- EC
- 3.2.2.-
- UniProt
- P12295, P14739
- Pockets
- 13 · best druggability 0.77
Structure
x-ray diffraction · 6 distinct chains · 35% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uracil-DNA glycosylase (EC 3.2.2.-) | protein | 223 | 43% helix, 12% strand | P12295 |
| B, F | Uracil-DNA glycosylase inhibitor | protein | 82 | 18% helix, 41% strand | P14739 |
| C, E | Uracil-DNA glycosylase (EC 3.2.2.-) | protein | 224 | 38% helix, 11% strand | P12295 |
| D | Uracil-DNA glycosylase inhibitor | protein | 83 | 22% helix, 40% strand | P14739 |
| G | Uracil-DNA glycosylase (EC 3.2.2.-) | protein | 225 | 38% helix, 11% strand | P12295 |
| H | Uracil-DNA glycosylase inhibitor | protein | 84 | 20% helix, 39% strand | P14739 |
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.77 | 0.98 | 37 | empty |
| 2 | 92 | 0.76 | 0.98 | 31 | empty |
| 3 | 88 | 0.76 | 0.98 | 35 | empty |
| 4 | 84 | 0.76 | 0.98 | 31 | empty |
| 5 | 469 | 0.65 | 0.78 | 55 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1096 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1090 Ų buried · 15 hydrogen bonds · protein-protein
- G–H · 1083 Ų buried · 17 hydrogen bonds · protein-protein
- E–F · 1075 Ų buried · 13 hydrogen bonds · protein-protein
- C–H · 207 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1LQM · Escherichia COLI uracil-DNA glycosylase complex with uracil-DNA glycosylase inhibitor… · the same entry in another collection · chain H against H, TM-score 1.00
- P12295 · AlphaFold monomer V2.0 prediction for uracil-DNA glycosylase (P12295) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12295
- Every structure of UniProt P14739
- Elsewhere: RCSB PDB 1LQM · PDBe 1LQM · UniProt P12295 · UniProt P14739
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