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Escherichia COLI uracil-DNA glycosylase

Analyse Escherichia COLI uracil-DNA glycosylase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1LQJ
Type: protein
Length: 909 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uracil-DNA glycosylase
EC: 3.2.2.-
UniProt: P12295
Pockets: 4 · best druggability 0.57

Structure

x-ray diffraction · 4 distinct chains · 35% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uracil-DNA glycosylase (EC 3.2.2.-)	protein	228	33% helix, 11% strand	P12295
B	Uracil-DNA glycosylase (EC 3.2.2.-)	protein	226	36% helix, 11% strand	P12295
C	Uracil-DNA glycosylase (EC 3.2.2.-)	protein	229	35% helix, 11% strand	P12295
D	Uracil-DNA glycosylase (EC 3.2.2.-)	protein	226	37% helix, 11% strand	P12295

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	146	0.57	0.82	41	empty
2	142	0.50	0.79	24	empty
3	97	0.43	0.79	25	empty
4	92	0.42	0.78	13	empty

Compared structures

1LQJ · Escherichia COLI uracil-DNA glycosylase · the same entry in another collection · chain D against D, TM-score 1.00
P12295 · AlphaFold monomer V2.0 prediction for uracil-DNA glycosylase (P12295) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12295
Elsewhere: RCSB PDB 1LQJ · PDBe 1LQJ · UniProt P12295

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