Research workbench
Escherichia COLI uracil-DNA glycosylase complex with uracil- DNA glycosylase inhibitor protein
Analyse Escherichia COLI uracil-DNA glycosylase complex with uracil- DNA glycosylase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1LQG
- Type
- protein
- Length
- 593 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uracil-DNA glycosylase; Uracil-DNA glycosylase inhibitor
- EC
- 3.2.2.-
- UniProt
- P12295, P14739
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 4 distinct chains · 29% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uracil-DNA glycosylase (EC 3.2.2.-) | protein | 226 | 35% helix, 10% strand | P12295 |
| B | Uracil-DNA glycosylase (EC 3.2.2.-) | protein | 224 | 35% helix, 11% strand | P12295 |
| C | Uracil-DNA glycosylase inhibitor | protein | 73 | 11% helix, 41% strand | P14739 |
| D | Uracil-DNA glycosylase inhibitor | protein | 70 | 11% helix, 47% strand | P14739 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.71 | 0.98 | 19 | empty |
| 2 | 61 | 0.70 | 0.97 | 26 | empty |
| 3 | 132 | 0.45 | 0.77 | 17 | empty |
| 4 | 129 | 0.38 | 0.74 | 27 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1070 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 1043 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 406 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1LQG · Escherichia COLI uracil-DNA glycosylase complex with uracil-DNA glycosylase inhibitor… · the same entry in another collection · chain A against A, TM-score 1.00
- P12295 · AlphaFold monomer V2.0 prediction for uracil-DNA glycosylase (P12295) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12295
- Every structure of UniProt P14739
- Elsewhere: RCSB PDB 1LQG · PDBe 1LQG · UniProt P12295 · UniProt P14739
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