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Crystal structure of anti-CCL17 antibody M116

Analyse Crystal structure of anti-CCL17 antibody M116 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5WK2
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: M116 light chain; M116 heavy chain
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	M116 light chain	protein	219	5% helix, 51% strand	—
H	M116 heavy chain	protein	217	9% helix, 52% strand	—

Ligands and binding sites

GOL · Glycerol · additive · 3 copies · chains L, H
EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · 2 copies · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	284	0.53	0.75	43	empty
2	157	0.44	0.75	31	empty
3	73	0.31	0.73	17	EPE
4	51	0.26	0.73	14	empty

Interfaces

1 interface between chains.

L–H · 1823 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5WK2 · Crystal structure of anti-CCL17 antibody M116 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5WK2 · PDBe 5WK2

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