Research workbench
Crystal structure of schizosaccharomyces pombe MIS16 in complex with EIC1
Analyse Crystal structure of schizosaccharomyces pombe MIS16 in complex with EIC1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5WJC
- Type
- protein
- Length
- 398 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinetochore protein MIS16; EIC1 protein
- UniProt
- O94244, O42995
- Pockets
- 2 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kinetochore protein MIS16 | protein | 384 | 11% helix, 45% strand | O94244 |
| B | EIC1 protein | protein | 14 | 57% helix, 0% strand | O42995 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 602 | 0.77 | 0.83 | 51 | empty |
| 2 | 70 | 0.35 | 0.77 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 919 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 5WJC · Crystal structure of Schizosaccharomyces pombe Mis16 in complex with Eic1 · the same entry in another collection · chain A against A, TM-score 1.00
- O94244 · AlphaFold monomer V2.0 prediction for histone acetyltransferase type B subunit 2 (O94244) · a predicted model of the same protein · chain A against A, TM-score 0.99
- O42995 · AlphaFold monomer V2.0 prediction for cenp-a recruiting complex protein MIS19 (O42995) · a predicted model of the same protein · chain B against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94244
- Every structure of UniProt O42995
- Elsewhere: RCSB PDB 5WJC · PDBe 5WJC · UniProt O94244 · UniProt O42995
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