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Crystal structure of the broadly neutralizing influenza a antibody vrc 315 27-1C08 Fab.

Analyse Crystal structure of the broadly neutralizing influenza a antibody vrc 315… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5WCA
Type: protein
Length: 437 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: VRC315 27-1C08 Fab heavy chain; VRC315 27-1C08 Fab light chain
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	VRC315 27-1C08 Fab heavy chain	protein	226	11% helix, 50% strand	—
L	VRC315 27-1C08 Fab light chain	protein	211	7% helix, 53% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	496	0.59	0.74	55	empty
2	118	0.43	0.77	24	empty
3	91	0.40	0.78	24	empty
4	78	0.32	0.74	13	empty

Interfaces

1 interface between chains.

H–L · 1838 Å² buried · 23 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5WCA · Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 27-1C08 Fab. · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5WCA · PDBe 5WCA

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