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Structure of a bacterial polysialyltransferase at 2.75 ångström resolution

Analyse Structure of a bacterial polysialyltransferase at 2.75 ångström resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5WC8
Type: protein
Length: 762 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Siad
UniProt: G4RIN4
Ligands: BR
Pockets: 6 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
M, A	Siad	protein	381	44% helix, 15% strand	G4RIN4

Ligands and binding sites

BR · Bromide ion · ion · 36 copies · chains M, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	957	0.72	0.76	68	BR
2	429	0.67	0.79	51	empty
3	327	0.54	0.74	42	BR
4	107	0.40	0.76	21	BR
5	129	0.37	0.73	18	empty

Interfaces

1 interface between chains.

M–A · 1081 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5WC8 · Structure of a bacterial polysialyltransferase at 2.75 Angstrom resolution · the same entry in another collection · chain M against M, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G4RIN4
Elsewhere: RCSB PDB 5WC8 · PDBe 5WC8 · UniProt G4RIN4

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