Research workbench
Crystal structure of JAK3 kinase domain with a 4,6-diaminonicotinamide inhibitor (compound number 7)
Analyse Crystal structure of JAK3 kinase domain with a 4,6-diaminonicotinamide… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5W86
- Type
- protein
- Length
- 1,089 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P52333
- Ligands
- 9YV
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 271 | — | P52333 |
| B | — | protein | 269 | — | P52333 |
| C | — | protein | 275 | — | P52333 |
| D | — | protein | 274 | — | P52333 |
Ligands and binding sites
- 9YV · 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl) carbamoyl]phenyl}amino)pyridine-3-carboxamide · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5W86 · Crystal structure of JAK3 kinase domain with a 4,6-diaminonicotinamide inhibitor… · the same entry in another collection · chain D against D, TM-score 1.00
- P52333 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase JAK3 (P52333) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52333
- Elsewhere: RCSB PDB 5W86 · PDBe 5W86 · UniProt P52333
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