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Crystal structure of the core catalytic domain of human inositol phosphate multikinase

Analyse Crystal structure of the core catalytic domain of human inositol phosphate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5W2G
Type: protein
Length: 234 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inositol polyphosphate MULTIKINASE,INOSITOL polyphosphate multikinase
EC: 2.7.1.151
UniProt: Q8NFU5
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inositol polyphosphate MULTIKINASE,INOSITOL polyphosphate multikinase (EC 2.7.1.151)	protein	234	36% helix, 26% strand	Q8NFU5

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	149	0.49	0.78	33	empty
2	148	0.43	0.75	20	empty

Compared structures

5W2G · Crystal structure of the core catalytic domain of human inositol phosphate multikinase · the same entry in another collection · chain A against A, TM-score 1.00
Q8NFU5 · AlphaFold monomer V2.0 prediction for inositol polyphosphate multikinase (Q8NFU5) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NFU5
Elsewhere: RCSB PDB 5W2G · PDBe 5W2G · UniProt Q8NFU5

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