Research workbench
CR1-07 unliganded Fab
Analyse CR1-07 unliganded Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5W1G
- Type
- protein
- Length
- 441 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CR1-07 Fab heavy chain; CR1-07 Fab light chain
- Pockets
- 6 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | CR1-07 Fab heavy chain | protein | 220 | 7% helix, 51% strand | — |
| L | CR1-07 Fab light chain | protein | 221 | 6% helix, 52% strand | — |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 421 | 0.55 | 0.73 | 46 | empty |
| 2 | 136 | 0.45 | 0.77 | 29 | empty |
| 3 | 96 | 0.39 | 0.76 | 24 | empty |
| 4 | 85 | 0.33 | 0.74 | 25 | empty |
| 5 | 64 | 0.30 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- H–L · 1702 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5W1G · CR1-07 unliganded Fab · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5W1G · PDBe 5W1G
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