Research workbench
Crystal structure of a lysosomal potassium-selective channel TMEM175 homolog from chamaesiphon minutus
Analyse Crystal structure of a lysosomal potassium-selective channel TMEM175 homolog… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5VRE
- Type
- protein
- Length
- 752 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative integral membrane protein
- UniProt
- K9UJK2
- Pockets
- 20 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Putative integral membrane protein | protein | 188 | 87% helix, 0% strand | K9UJK2 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 106 | 0.78 | 0.97 | 19 | empty |
| 2 | 96 | 0.78 | 0.98 | 16 | empty |
| 3 | 74 | 0.75 | 0.98 | 19 | empty |
| 4 | 67 | 0.74 | 0.98 | 17 | empty |
| 5 | 648 | 0.70 | 0.77 | 46 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1431 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 1409 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 1404 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 1393 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 14 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5VRE · Crystal structure of a lysosomal potassium-selective channel TMEM175 homolog from… · the same entry in another collection · chain A against A, TM-score 1.00
- K9UJK2 · AlphaFold monomer V2.0 prediction for potassium channel CHA6605_3372 (K9UJK2) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt K9UJK2
- Elsewhere: RCSB PDB 5VRE · PDBe 5VRE · UniProt K9UJK2
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