Research workbench
Solution-state NMR structural ensemble of human TSG101 uev in complex with tenatoprazole
Analyse Solution-state NMR structural ensemble of human TSG101 uev in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5VKG
- Type
- protein
- Length
- 144 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor susceptibility gene 101 protein
- UniProt
- Q99816
- Ligands
- 4N1
- Pockets
- 1 · best druggability 0.42
Structure
solution nmr · 1 distinct chain · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor susceptibility gene 101 protein | protein | 144 | 26% helix, 32% strand | Q99816 |
Ligands and binding sites
- 4N1 · 4-methoxy-1-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)-3,5-dimethyl-2-(sulfanylmethyl)pyridin-1-ium · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.42 | 0.80 | 14 | empty |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 5VKG · Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole · the same entry in another collection · chain A against A, TM-score 1.00
- Q99816 · AlphaFold monomer V2.0 prediction for tumor susceptibility gene 101 protein (Q99816) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99816
- Elsewhere: RCSB PDB 5VKG · PDBe 5VKG · UniProt Q99816
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.