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Crystal structure of human MDM2 in complex with a 12-mer lysine- cysteine side chain dithiocarbamate stapled peptide inhibitor pmi
Analyse Crystal structure of human MDM2 in complex with a 12-mer lysine- cysteine side… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5VK0
- Type
- protein
- Length
- 1,156 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q00987
- Ligands
- ACE, NH2, CL
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, G, I, K, M, S | — | protein | 85 | — | Q00987 |
| B, D, F, H, J, L, N, P, R, T, V, X | — | protein | 12 | — | — |
| E, O, Q | — | protein | 83 | — | Q00987 |
| U, W | — | protein | 84 | — | Q00987 |
Ligands and binding sites
- ACE · Acetyl group · ligand · 12 copies · chains B, M, D, F, K, H, Q, J, E, L, A, N, P, G, R, T, U, S, V, X
- NH2 · Amino group · ion · 12 copies · chains B, D, I, F, Q, H, J, L, N, P, R, T, V, X
- CL · Chloride ion · ion · 2 copies · chains C, W, X
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5VK0 · Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00987
- Elsewhere: RCSB PDB 5VK0 · PDBe 5VK0 · UniProt Q00987
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