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Cryo-EM structure of the human ether-a-go-go related K+ channel

Analyse Cryo-EM structure of the human ether-a-go-go related K+ channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5VA3
Type: protein
Length: 559 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium voltage-gated channel subfamily H member 2
UniProt: Q12809
Pockets: 5 · best druggability 0.63

Structure

electron microscopy · 1 distinct chain · 50% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Potassium voltage-gated channel subfamily H member 2	protein	559	50% helix, 13% strand	Q12809

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	314	0.63	0.79	21	empty
2	140	0.45	0.76	21	empty
3	173	0.45	0.75	33	empty
4	179	0.44	0.74	24	empty
5	58	0.31	0.76	14	empty

Compared structures

5VA3 · Cryo-EM structure of the human ether-a-go-go related K+ channel · the same entry in another collection · chain A against A, TM-score 1.00
Q12809 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily H member… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12809
Elsewhere: RCSB PDB 5VA3 · PDBe 5VA3 · UniProt Q12809

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