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Cryo-EM structure of the human ether-a-go-go related K+ channel

Analyse Cryo-EM structure of the human ether-a-go-go related K+ channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5VA2
Type: protein
Length: 558 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium voltage-gated channel subfamily H member 2
UniProt: Q12809
Pockets: 7 · best druggability 0.63

Structure

electron microscopy · 1 distinct chain · 51% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Potassium voltage-gated channel subfamily H member 2	protein	558	51% helix, 12% strand	Q12809

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	288	0.63	0.80	21	empty
2	138	0.47	0.77	22	empty
3	151	0.44	0.75	23	empty
4	71	0.42	0.81	16	empty
5	104	0.37	0.74	20	empty

Compared structures

5VA2 · Cryo-EM structure of the human ether-a-go-go related K+ channel · the same entry in another collection · chain A against A, TM-score 1.00
Q12809 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily H member… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12809
Elsewhere: RCSB PDB 5VA2 · PDBe 5VA2 · UniProt Q12809

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