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The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding

Analyse The crystal structure and biological function of leukemia inhibitory factor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1LKI
Type: protein
Length: 172 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Leukemia inhibitory factor
UniProt: P09056
Pockets: 2 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leukemia inhibitory factor	protein	172	67% helix, 2% strand	P09056

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	170	0.63	0.84	22	empty
2	70	0.31	0.74	18	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

1LKI · The crystal structure and biological function of leukemia inhibitory factor: implications… · the same entry in another collection · chain A against A, TM-score 1.00
P09056 · AlphaFold monomer V2.0 prediction for leukemia inhibitory factor (P09056) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09056
Elsewhere: RCSB PDB 1LKI · PDBe 1LKI · UniProt P09056

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