Research workbench
Cryptococcus neoformans adenylosuccinate lyase
Analyse Cryptococcus neoformans adenylosuccinate lyase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5V4L
- Type
- protein
- Length
- 1,829 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylosuccinate lyase
- EC
- 4.3.2.2
- UniProt
- J9VSX1
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 69% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylosuccinate lyase (EC 4.3.2.2) | protein | 457 | 70% helix, 4% strand | J9VSX1 |
| B | Adenylosuccinate lyase (EC 4.3.2.2) | protein | 454 | 69% helix, 4% strand | J9VSX1 |
| C | Adenylosuccinate lyase (EC 4.3.2.2) | protein | 467 | 67% helix, 4% strand | J9VSX1 |
| D | Adenylosuccinate lyase (EC 4.3.2.2) | protein | 451 | 69% helix, 4% strand | J9VSX1 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 404 | 0.86 | 0.94 | 39 | empty |
| 2 | 379 | 0.85 | 0.94 | 36 | empty |
| 3 | 150 | 0.80 | 0.97 | 30 | empty |
| 4 | 135 | 0.79 | 0.97 | 29 | empty |
| 5 | 992 | 0.77 | 0.79 | 82 | empty |
Interfaces
6 interfaces between chains.
- A–B · 3552 Ų buried · 75 hydrogen bonds · protein-protein
- C–D · 3521 Ų buried · 77 hydrogen bonds · protein-protein
- A–C · 2336 Ų buried · 38 hydrogen bonds · protein-protein
- B–D · 2129 Ų buried · 35 hydrogen bonds · protein-protein
- B–C · 2066 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 5V4L · Cryptococcus neoformans adenylosuccinate lyase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt J9VSX1
- Elsewhere: RCSB PDB 5V4L · PDBe 5V4L · UniProt J9VSX1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.