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Crystal structure of the SR1 domain of lizard sacsin

Analyse Crystal structure of the SR1 domain of lizard sacsin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5V47
Type: protein
Length: 461 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lizard sacsin
UniProt: G1KBF9
Ligands: SO4
Pockets: 7 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lizard sacsin	protein	231	35% helix, 23% strand	G1KBF9
B	Lizard sacsin	protein	230	35% helix, 23% strand	G1KBF9

Ligands and binding sites

SO4 · Sulfate ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	198	0.54	0.79	34	empty
2	86	0.43	0.79	19	empty
3	66	0.42	0.80	12	empty
4	54	0.32	0.77	15	empty
5	89	0.32	0.73	24	empty

Interfaces

1 interface between chains.

A–B · 366 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

5V47 · Crystal structure of the SR1 domain of lizard sacsin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G1KBF9
Elsewhere: RCSB PDB 5V47 · PDBe 5V47 · UniProt G1KBF9

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