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Crystal structure of the I113M, F270M, K291M, L308M mutant of SR1 domain of human sacsin

Analyse Crystal structure of the I113M, F270M, K291M, L308M mutant of SR1 domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5V46
Type: protein
Length: 494 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sacsin
UniProt: Q9NZJ4
Pockets: 5 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sacsin	protein	252	35% helix, 22% strand	Q9NZJ4
B	Sacsin	protein	242	35% helix, 23% strand	Q9NZJ4

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	299	0.67	0.82	44	empty
2	122	0.47	0.79	20	empty
3	85	0.35	0.75	18	empty
4	54	0.31	0.77	15	empty
5	55	0.31	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 431 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

5V46 · Crystal structure of the I113M, F270M, K291M, L308M mutant of SR1 domain of human sacsin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NZJ4
Elsewhere: RCSB PDB 5V46 · PDBe 5V46 · UniProt Q9NZJ4

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