Research workbench
CHMP4C in complex with alix BRO1
Analyse CHMP4C in complex with alix BRO1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5V3R
- Type
- protein
- Length
- 370 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Programmed cell death 6-interacting protein; Charged multivesicular body protein 4C
- UniProt
- Q8WUM4, Q96CF2
- Pockets
- 5 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Programmed cell death 6-interacting protein | protein | 357 | 58% helix, 3% strand | Q8WUM4 |
| B | Charged multivesicular body protein 4C | protein | 13 | 85% helix, 0% strand | Q96CF2 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.55 | 0.85 | 23 | empty |
| 2 | 254 | 0.54 | 0.76 | 23 | empty |
| 3 | 52 | 0.47 | 0.86 | 19 | empty |
| 4 | 59 | 0.40 | 0.80 | 14 | empty |
| 5 | 71 | 0.33 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 502 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5V3R · CHMP4C in complex with ALIX BRO1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WUM4 · AlphaFold monomer V2.0 prediction for programmed cell death 6-interacting protein (Q8WUM4) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q96CF2 · AlphaFold monomer V2.0 prediction for charged multivesicular body protein 4C (Q96CF2) · a predicted model of the same protein · chain B against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WUM4
- Every structure of UniProt Q96CF2
- Elsewhere: RCSB PDB 5V3R · PDBe 5V3R · UniProt Q8WUM4 · UniProt Q96CF2
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