Research workbench
Structure of PHD1 in complex with 1,2,4-triazolo-[1,5-A]PYRIDINE
Analyse Structure of PHD1 in complex with 1,2,4-triazolo-[1,5-A]PYRIDINE in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5V1B
- Type
- protein
- Length
- 226 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Egl nine homolog 2
- EC
- 1.14.11.29
- UniProt
- Q96KS0
- Ligands
- 8UY, FE, SO4
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Egl nine homolog 2 (EC 1.14.11.29) | protein | 226 | 29% helix, 27% strand | Q96KS0 |
Ligands and binding sites
- 8UY · 4-([1,2,4]triazolo[1,5-a]pyridin-5-yl)benzonitrile · ligand · chains A
- FE · Fe (III) ion · metal · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 407 | 0.68 | 0.80 | 47 | SO4, 8UY |
Compared structures
- 5V1B · Structure of PHD1 in complex with 1,2,4-Triazolo-[1,5-a]pyridine · the same entry in another collection · chain A against A, TM-score 1.00
- Q96KS0 · AlphaFold monomer V2.0 prediction for prolyl hydroxylase EGLN2 (Q96KS0) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96KS0
- Elsewhere: RCSB PDB 5V1B · PDBe 5V1B · UniProt Q96KS0
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