Research workbench
Structure of E. COLI mce protein mlad, periplasmic domain
Analyse Structure of E. COLI mce protein mlad, periplasmic domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UW2
- Type
- protein
- Length
- 332 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable phospholipid ABC transporter-binding protein mlad
- UniProt
- P64605
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable phospholipid ABC transporter-binding protein mlad | protein | 112 | 8% helix, 43% strand | P64605 |
| B, C | Probable phospholipid ABC transporter-binding protein mlad | protein | 110 | 8% helix, 44% strand | P64605 |
Ligands and binding sites
- ZN · Zinc ion · metal · 6 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 419 | 0.66 | 0.79 | 53 | empty |
| 2 | 190 | 0.53 | 0.78 | 31 | empty |
| 3 | 69 | 0.33 | 0.75 | 21 | empty |
| 4 | 51 | 0.29 | 0.76 | 17 | empty |
Interfaces
2 interfaces between chains.
- B–C · 879 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 876 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5UW2 · Structure of E. coli MCE protein MlaD, periplasmic domain · the same entry in another collection · chain A against A, TM-score 1.00
- P64605 · AlphaFold monomer V2.0 prediction for intermembrane phospholipid transport system binding… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P64605
- Elsewhere: RCSB PDB 5UW2 · PDBe 5UW2 · UniProt P64605
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