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Crystal structure of TNMS1, an antibiotic binding protein from streptomyces sp. CB03234

Analyse Crystal structure of TNMS1, an antibiotic binding protein from streptomyces sp.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5UMQ
Type: protein
Length: 251 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GLYOXALASE/BLEOMYCIN resisance PROTEIN/DIOXYGENASE
UniProt: A0A125SA24
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GLYOXALASE/BLEOMYCIN resisance PROTEIN/DIOXYGENASE	protein	125	17% helix, 47% strand	A0A125SA24
B	GLYOXALASE/BLEOMYCIN resisance PROTEIN/DIOXYGENASE	protein	126	17% helix, 45% strand	A0A125SA24

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	278	0.57	0.77	39	empty
2	247	0.55	0.77	30	empty

Interfaces

1 interface between chains.

A–B · 1871 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

5UMQ · Crystal structure of TnmS1, an antibiotic binding protein from Streptomyces sp. CB03234 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A125SA24
Elsewhere: RCSB PDB 5UMQ · PDBe 5UMQ · UniProt A0A125SA24

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