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Structure of a human bence-jones dimer crystallized in U.S. space shuttle mission sts-95: 293K

Analyse Structure of a human bence-jones dimer crystallized in U.S. space shuttle… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1LHZ
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Immunoglobulin lambda light chain
Pockets: 5 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Immunoglobulin lambda light chain	protein	214	6% helix, 49% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	250	0.64	0.81	34	empty
2	270	0.49	0.73	50	empty
3	154	0.45	0.75	33	empty
4	93	0.37	0.75	26	empty
5	54	0.28	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 1723 Å² buried · 25 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 2 modified (disulfide, cyclization).

Compared structures

1LHZ · Structure of a Human Bence-Jones Dimer Crystallized in U.S. Space Shuttle Mission STS-95… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1LHZ · PDBe 1LHZ

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