Research workbench
Crystal structure of human T2-tryptophanyl-tRNA synthetase with H130R mutation
Analyse Crystal structure of human T2-tryptophanyl-tRNA synthetase with H130R mutation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UJI
- Type
- protein
- Length
- 710 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan--tRNA ligase, cytoplasmic
- EC
- 6.1.1.2
- UniProt
- P23381
- Pockets
- 9 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) | protein | 356 | 52% helix, 9% strand | P23381 |
| B | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) | protein | 354 | 57% helix, 8% strand | P23381 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 674 | 0.76 | 0.81 | 51 | empty |
| 2 | 459 | 0.70 | 0.81 | 33 | empty |
| 3 | 262 | 0.61 | 0.80 | 28 | empty |
| 4 | 78 | 0.59 | 0.88 | 18 | empty |
| 5 | 140 | 0.53 | 0.81 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1612 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 5UJI · Crystal structure of human T2-Tryptophanyl-tRNA synthetase with H130R mutation · the same entry in another collection · chain A against A, TM-score 1.00
- P23381 · AlphaFold monomer V2.0 prediction for tryptophan--tRNA ligase, cytoplasmic (P23381) · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23381
- Elsewhere: RCSB PDB 5UJI · PDBe 5UJI · UniProt P23381
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