Research workbench

Crystal structure of the DH576 CD4BS Fab (unliganded) from the RV305 HIV vaccine trial

Analyse Crystal structure of the DH576 CD4BS Fab (unliganded) from the RV305 HIV… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5UIX
Type: protein
Length: 439 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DH576 Fab heavy chain; DH576 Fab light chain
Pockets: 4 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	DH576 Fab heavy chain	protein	226	8% helix, 47% strand	—
L	DH576 Fab light chain	protein	213	6% helix, 52% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	670	0.63	0.74	67	empty
2	87	0.38	0.76	20	empty
3	91	0.33	0.73	19	empty
4	59	0.28	0.73	16	empty

Interfaces

1 interface between chains.

H–L · 1683 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5UIX · Crystal Structure of the DH576 CD4bs Fab (unliganded) from the RV305 HIV Vaccine Trial · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5UIX · PDBe 5UIX

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.