Research workbench
A human antibody against zika virus crosslinks the E protein to prevent infection
Analyse A human antibody against zika virus crosslinks the E protein to prevent… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UHY
- Type
- protein
- Length
- 2,052 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ZV67 Fab chain 1; ZV67 Fab chain 2; Envelope protein
- UniProt
- A0A120IIH7
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 3 distinct chains · 5% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G, I | ZV67 Fab chain 1 | protein | 214 | 5% helix, 51% strand | — |
| H, J | ZV67 Fab chain 2 | protein | 218 | 7% helix, 46% strand | — |
| C, E, A | Envelope protein | protein | 396 | 5% helix, 35% strand | A0A120IIH7 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1041 | 0.82 | 0.83 | 101 | empty |
| 2 | 943 | 0.74 | 0.77 | 85 | empty |
| 3 | 641 | 0.72 | 0.79 | 82 | empty |
| 4 | 54 | 0.67 | 0.96 | 23 | empty |
| 5 | 475 | 0.66 | 0.78 | 53 | empty |
Interfaces
11 interfaces between chains.
- I–J · 1729 Ų buried · 26 hydrogen bonds · protein-protein
- G–H · 1596 Ų buried · 23 hydrogen bonds · protein-protein
- G–I · 1424 Ų buried · 199 hydrogen bonds · protein-protein
- C–E · 1113 Ų buried · 5 hydrogen bonds · protein-protein
- C–A · 959 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide, 2 isopeptide (disulfide, isopeptide).
Compared structures
- 5UHY · A Human Antibody Against Zika Virus Crosslinks the E Protein to Prevent Infection · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A120IIH7
- Elsewhere: RCSB PDB 5UHY · PDBe 5UHY · UniProt A0A120IIH7
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