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Structure of the PP2C phosphatase domain and a fragment of the regulatory domain of the cell fate determinant spoiie from bacillus subtilis
Analyse Structure of the PP2C phosphatase domain and a fragment of the regulatory… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UCG
- Type
- protein
- Length
- 1,685 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Stage II sporulation protein E
- EC
- 3.1.3.16
- UniProt
- P37475
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 5 distinct chains · 33% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Stage II sporulation protein E (EC 3.1.3.16) | protein | 345 | 34% helix, 26% strand | P37475 |
| E | Stage II sporulation protein E (EC 3.1.3.16) | protein | 338 | 34% helix, 25% strand | P37475 |
| B | Stage II sporulation protein E (EC 3.1.3.16) | protein | 337 | 33% helix, 23% strand | P37475 |
| C | Stage II sporulation protein E (EC 3.1.3.16) | protein | 331 | 34% helix, 25% strand | P37475 |
| D | Stage II sporulation protein E (EC 3.1.3.16) | protein | 334 | 33% helix, 27% strand | P37475 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 216 | 0.79 | 0.92 | 36 | empty |
| 2 | 1086 | 0.78 | 0.80 | 109 | empty |
| 3 | 468 | 0.74 | 0.83 | 50 | empty |
| 4 | 754 | 0.73 | 0.79 | 78 | empty |
| 5 | 203 | 0.63 | 0.82 | 31 | empty |
Interfaces
8 interfaces between chains.
- C–D · 2100 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 1927 Ų buried · 17 hydrogen bonds · protein-protein
- E–D · 1367 Ų buried · 28 hydrogen bonds · protein-protein
- B–C · 1328 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 284 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5UCG · Structure of the PP2C Phosphatase Domain and a Fragment of the Regulatory Domain of the… · the same entry in another collection · chain D against D, TM-score 1.00
- P37475 · AlphaFold monomer V2.0 prediction for stage II sporulation protein E (P37475) · a predicted model of the same protein · chain E against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37475
- Elsewhere: RCSB PDB 5UCG · PDBe 5UCG · UniProt P37475
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