Research workbench
Crystal structure of methionyl-tRNA formyltransferase from pseudomonas aeruginosa
Analyse Crystal structure of methionyl-tRNA formyltransferase from pseudomonas… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5UAI
- Type
- protein
- Length
- 1,243 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methionyl-tRNA formyltransferase
- EC
- 2.1.2.9
- UniProt
- O85732
- Pockets
- 5 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methionyl-tRNA formyltransferase (EC 2.1.2.9) | protein | 310 | 27% helix, 28% strand | O85732 |
| B, C, D | Methionyl-tRNA formyltransferase (EC 2.1.2.9) | protein | 311 | 28% helix, 28% strand | O85732 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1124 | 0.85 | 0.86 | 111 | empty |
| 2 | 692 | 0.80 | 0.84 | 61 | empty |
| 3 | 643 | 0.79 | 0.84 | 56 | empty |
| 4 | 112 | 0.39 | 0.76 | 22 | empty |
| 5 | 91 | 0.33 | 0.74 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1225 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 1142 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 250 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5UAI · Crystal structure of Methionyl-tRNA formyltransferase from Pseudomonas aeruginosa · the same entry in another collection · chain D against D, TM-score 1.00
- O85732 · AlphaFold monomer V2.0 prediction for methionyl-tRNA formyltransferase (O85732) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O85732
- Elsewhere: RCSB PDB 5UAI · PDBe 5UAI · UniProt O85732
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.