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Solution structure of the zinc fingers 1 and 2 of MBNL1 in complex with human cardiac troponin T pre-mRNA

Analyse Solution structure of the zinc fingers 1 and 2 of MBNL1 in complex with human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5U9B
Type: protein + RNA
Length: 107 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Muscleblind-like protein 1; RNA (5'-R(P*GP*UP*CP*UP*CP*GP*CP*UP*UP*UP*UP*CP*CP*CP*C)- 3')
UniProt: Q9NR56
Ligands: ZN

Structure

solution nmr · 2 distinct chains · 28% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Muscleblind-like protein 1	protein	92	28% helix, 12% strand	Q9NR56
B	RNA (5'-R(PGPUPCPUPCPGPCPUPUPUPUPCPCPCP*C)- 3')	rna	15	—	—

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 1360 Å² buried · 34 hydrogen bonds · protein-nucleic

Compared structures

5U9B · Solution structure of the zinc fingers 1 and 2 of MBNL1 in complex with human cardiac… · the same entry in another collection · chain A against A, TM-score 1.00
Q9NR56 · AlphaFold monomer V2.0 prediction for muscleblind-like protein 1 (Q9NR56) · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

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Every structure of UniProt Q9NR56
Elsewhere: RCSB PDB 5U9B · PDBe 5U9B · UniProt Q9NR56

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