Research workbench
Solution structures of BRD2 second bromodomain in complex with STAT3 peptide
Analyse Solution structures of BRD2 second bromodomain in complex with STAT3 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5U5S
- Type
- protein
- Length
- 124 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain-containing protein 2; STAT3 peptide
- UniProt
- P25440
Structure
solution nmr · 2 distinct chains · 64% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bromodomain-containing protein 2 | protein | 112 | 71% helix, 0% strand | P25440 |
| B | STAT3 peptide | protein | 12 | 0% helix, 0% strand | — |
Interfaces
1 interface between chains.
- A–B · 723 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 5U5S · Solution structures of Brd2 second bromodomain in complex with stat3 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P25440 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 2 (P25440) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25440
- Elsewhere: RCSB PDB 5U5S · PDBe 5U5S · UniProt P25440
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