Research workbench
Crystal structure of DH511.4 Fab
Analyse Crystal structure of DH511.4 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5U3P
- Type
- protein
- Length
- 446 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DH511.4 Fab heavy chain; DH511.4 Fab light chain
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | DH511.4 Fab heavy chain | protein | 232 | 12% helix, 53% strand | — |
| L | DH511.4 Fab light chain | protein | 214 | 7% helix, 50% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 395 | 0.55 | 0.74 | 54 | empty |
| 2 | 80 | 0.34 | 0.75 | 18 | empty |
| 3 | 65 | 0.29 | 0.73 | 20 | empty |
Interfaces
1 interface between chains.
- H–L · 2043 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5U3P · Crystal Structure of DH511.4 Fab · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5U3P · PDBe 5U3P
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