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RNA-DNA heptamer duplex with one 2'-5'-linkage

Analyse RNA-DNA heptamer duplex with one 2'-5'-linkage in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
5U0Q
Type
RNA
Length
28 nucleotides
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
RNA (5'-R(*UP*AP*GP*CP*UP*CP*C)-3'); DNA/RNA (5'-R(*GP*GP*AP*GP*C)-D(P*T)-R(P*A)-3')
Ligands
MG, CO

Structure

x-ray diffraction · 2 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A, CRNA (5'-R(*UP*AP*GP*CP*UP*CP*C)-3')rna7——
B, DDNA/RNA (5'-R(*GP*GP*AP*GP*C)-D(P*T)-R(P*A)-3')rna7——

Ligands and binding sites

  • MG · Magnesium ion · metal · 3 copies · chains B, C, D
  • CO · Cobalt (II) ion · metal · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

  • C–D · 368 Ų buried · 27 hydrogen bonds · nucleic-nucleic
  • A–B · 361 Ų buried · 23 hydrogen bonds · nucleic-nucleic
  • B–C · 90 Ų buried · 3 hydrogen bonds · nucleic-nucleic
  • A–D · 87 Ų buried · 2 hydrogen bonds · nucleic-nucleic
  • B–D · 83 Ų buried · 4 hydrogen bonds · nucleic-nucleic

Compared structures

  • 5U0Q · RNA-DNA heptamer duplex with one 2'-5'-linkage · the same entry in another collection · chain A against A, TM-score 1.00

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