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Structure of full-length zika virus NS5

Analyse Structure of full-length zika virus NS5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5U0B
Type: protein
Length: 1,766 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
EC: 2.1.1.56, 2.1.1.57, 2.7.7.48
UniProt: Q32ZE1
Ligands: SAH, ZN, SO4
Pockets: 14 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Genome polyprotein (EC 2.1.1.56, 2.1.1.57, 2.7.7.48)	protein	883	42% helix, 13% strand	Q32ZE1

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains A, B
ZN · Zinc ion · metal · 4 copies · chains A, B
SO4 · Sulfate ion · ion · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	974	0.80	0.82	86	SO4
2	875	0.78	0.81	86	SO4
3	562	0.65	0.76	50	SAH, SO4
4	553	0.65	0.76	50	SAH
5	369	0.58	0.76	42	empty

Interfaces

1 interface between chains.

A–B · 1328 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

5U0B · Structure of full-length Zika virus NS5 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q32ZE1
Elsewhere: RCSB PDB 5U0B · PDBe 5U0B · UniProt Q32ZE1

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