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X-ray crystal structure of the aspergillus fumigatus sliding clamp

Analyse X-ray crystal structure of the aspergillus fumigatus sliding clamp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TUP
Type: protein
Length: 763 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proliferating cell nuclear antigen
UniProt: A0A0J5SJF1
Pockets: 3 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Proliferating cell nuclear antigen	protein	254	17% helix, 44% strand	A0A0J5SJF1
C	Proliferating cell nuclear antigen	protein	255	18% helix, 45% strand	A0A0J5SJF1

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.39	0.78	16	empty
2	107	0.36	0.74	30	empty
3	74	0.32	0.74	25	empty

Interfaces

3 interfaces between chains.

A–C · 725 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 692 Å² buried · 13 hydrogen bonds · protein-protein
B–C · 660 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

5TUP · X-ray Crystal Structure of the Aspergillus fumigatus Sliding Clamp · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0J5SJF1
Elsewhere: RCSB PDB 5TUP · PDBe 5TUP · UniProt A0A0J5SJF1

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