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Determining the molecular basis for starter unit selection during daunorubicin biosynthesis

Analyse Determining the molecular basis for starter unit selection during daunorubicin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TT4
Type: protein
Length: 680 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Daunorubicin-doxorubicin polyketide synthase
EC: 2.3.1.-
UniProt: Q54816
Pockets: 5 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Daunorubicin-doxorubicin polyketide synthase (EC 2.3.1.-)	protein	341	41% helix, 23% strand	Q54816
B	Daunorubicin-doxorubicin polyketide synthase (EC 2.3.1.-)	protein	339	40% helix, 23% strand	Q54816

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	360	0.73	0.84	41	empty
2	387	0.73	0.83	42	empty
3	290	0.71	0.85	44	empty
4	88	0.30	0.72	16	empty
5	50	0.22	0.71	13	empty

Interfaces

1 interface between chains.

A–B · 2832 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

5TT4 · Determining the Molecular Basis For Starter Unit Selection During Daunorubicin… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q54816
Elsewhere: RCSB PDB 5TT4 · PDBe 5TT4 · UniProt Q54816

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